Background/Objectives: The COVID-19 pandemic imposed logistical challenges on health systems, particularly for mass vaccination campaigns under emergency conditions. In decentralized health systems, the absence of a structured preparedness phase may compromise coordination, allocation, and operational performance. This study analyzes the vaccination campaign in a municipality in southern Brazil, examining how the overlap of the preparedness and response phases affected outcomes and how alternative logistical scenarios could have altered campaign performance. Methods: An empirical analysis was conducted using scenario-based simulation with stock and flow structures. The model represents vaccine procurement, distribution across national, state, regional, and municipal levels, and municipal vaccination capacity. Real data from the 2021 vaccination campaign in the municipality were used to build a Business-as-Usual scenario, compared with alternative scenarios involving changes in procurement predictability, allocation rules, and operational capacity. Results: Vaccination outcomes were strongly conditioned by upstream allocation decisions, particularly at the national state level. Isolated adjustments at intermediate supply chain levels produced limited improvements when upstream constraints persisted. Scenarios combining improved alignment between forecasted and acquired doses with operational capacity showed higher vaccination potential, revealing a gap between observed performance and system capacity. Conclusions: The findings reinforce that preparedness is a critical determinant of vaccination performance and must precede response in emergency contexts. Supply predictability alone is insufficient without coordinated allocation mechanisms and operational readiness across governance levels. This study provides empirical evidence on how preparation-related decisions shape vaccination outcomes in decentralized health systems and inform logistical coordination in future emergencies.
RÍVOLLI et al. (Thu,) studied this question.