ABSTRACT A simple and convenient approach was implemented in this study to synthesize Palladium nanoparticles (PdNPs) and single‐walled carbon nanotubes (SWCNTs) decorated chitosan (CS)‐based electrocatalyst for the first time to detect acetaminophen (AC) biomolecule. The SWCNTs enhance the catalytic capabilities of the as‐fabricated nanocomposite by preventing CS from aggregating and establishing a direct link with PdNPs. Characterization of the newly developed nanocomposite was carried out with several microscopic and spectroscopic techniques. The neutral pH medium shows the highest electrochemical performances under optimized conditions. The electron transfer coefficient was obtained α = 0.721, overall electron transfer n = 2. Differential pulse voltammetry (DPV) was employed for the sensing study, where excellent linearity was obtained with a linear range of 2.31 to 42.04 µM. DPV reveals a remarkable sensitivity of 2.43 µAµM −1 cm −2 , and LOD was 0.056 µM. In addition, the i‐t curve shows the experimental AC range 5 to 120 µM, and the obtained sensitivity and LOD are 2.35 µAµM −1 cm −2 and 0.058 µM, respectively. Furthermore, the newly developed sensor electrode exhibited outstanding stability, excellent repeatability, and outstanding selectivity even in the presence of commonly used interfering substances. Pharmaceutical formulation (paracetamol tablet) and human urine were used as real samples to recover AC for the assurance of the sensor in the real world. These outcomes of the study emphasize that the synthesized nanocomposite has potential applications for the fabrication of a sophisticated electrochemical AC sensor for clinical and pharmacological monitoring.
Rahman et al. (Wed,) studied this question.