Rapid Synthesis of Nucleoside Diphosphates Accelerated by Water

Key Points

• The research aims to develop an efficient method for synthesizing nucleoside diphosphates under aqueous conditions.
• Utilized chloro(phenyl)trifluoromethyliodane as a reagent for phosphoanhydride bond formation.
• Implemented a water-triggered synthesis strategy.
• Successfully demonstrated nucleoside diphosphate synthesis in the presence of water.
• Achieved rapid formation of phosphoanhydride bonds compared to traditional methods.