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This study examines the predictors of invasive differentiated thyroid carcinoma (DTC) in pediatric patients.

April 26, 2026The Journal of Clinical Endocrinology & Metabolism0 citations

The Landscape of Pediatric Differentiated Thyroid Carcinoma and Predictors of Invasive Disease: A CATC Study

JWJonathan D Wasserman AIAmber IsazaChildren's Hospital of Philadelphia SWSteven G. WaguespackThe University of Texas MD Anderson Cancer Center

Key Points

This study examines the predictors of invasive differentiated thyroid carcinoma (DTC) in pediatric patients.
Analysis of pediatric patients diagnosed with differentiated thyroid carcinoma (DTC)
Identification of associations between age, sex, tumor characteristics, and extrathyroidal extension (ETE)
Evaluation of long-term disease outcomes against recent treatment trends
Invasive DTC is significantly associated with age under 10 years and male sex.
Tumors characterized by oncogenic fusions are linked to higher rates of invasive disease.
Despite less aggressive treatment protocols, the outcomes of disease have remained stable.

Abstract

Invasive DTC is associated with age <10 years, male sex, tumors driven by oncogenic fusions and ETE. Despite less aggressive therapies in recent years, disease outcomes have not worsened. Recognition of these associations may guide care and prognostication.

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