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June 6, 2002New England Journal of Medicine4,043 citationsOpen Access

A Randomized Comparison of a Sirolimus-Eluting Stent with a Standard Stent for Coronary Revascularization

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MMMarie‐Claude MoriceInterventional Cardiology
Patrick W. Serruys
Patrick W. SerruysInterventional / Structural Cardiology
JSJ. Eduardo SousaCentro de Medicina de Reabilitacao do Alcoitão

Structured PICO

Does a sirolimus-eluting stent prevent neointimal proliferation, restenosis, and associated clinical events compared to a standard coronary stent in patients requiring coronary revascularization?

P
Population
Patients requiring coronary revascularization
I
Intervention
Sirolimus-eluting stent
C
Comparator
Standard coronary stent
O
Outcome
Neointimal proliferation, restenosis, and associated clinical events

A sirolimus-eluting stent shows promise in preventing restenosis and clinical events compared to standard stents for coronary revascularization.

Abstract

As compared with a standard coronary stent, a sirolimus-eluting stent shows considerable promise for the prevention of neointimal proliferation, restenosis, and associated clinical events.

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Cite This Study

Morice et al. (2002) studied this question.

synapsesocial.com/papers/69eede74a84321e0ae63c415https://doi.org/10.1056/nejmoa012843
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Small stent size and intimal hyperplasia contribute to restenosis: A volumetric intravascular ultrasound analysis1995 · 326 citations
  2. 2Anti-restenosis Trials.2000 · 33 citations
  3. 3Data and Safety Monitoring Boards2002 · 48 citations
  4. 4Intravascular Stents to Prevent Occlusion and Re-Stenosis after Transluminal Angioplasty1987 · 1,895 citations
  5. 5Intracoronary stenting for acute and threatened closure complicating percutaneous transluminal coronary angioplasty.1992 · 586 citations