Highlights that unlike HFrEF, the impairment of diastolic calcium homeostasis in HFpEF depends on the underlying etiology.
Although t-tubule disruption and impaired cardiomyocyte Ca2+ release are hallmarks of HFrEF, such changes are not prominent in HFpEF. Impaired diastolic Ca2+ homeostasis occurs in both conditions, but in HFpEF, this mechanism for diastolic dysfunction is etiology-dependent.
Frisk et al. (Mon,) studied this question.