Rare antigen‐negative red blood cells from pluripotent stem cells for precision transfusion medicine

Key Points

• The aim is to develop a method for generating rare antigen-negative red blood cells (RBCs) using induced pluripotent stem cells (iPSCs) for better transfusion matching.
• Utilized iPSC technology combined with gene editing to produce rare antigen-negative RBCs.
• Focused on creating additional rare RBC phenotypes for enhanced precision in transfusion medicine.
• Demonstrated successful generation of rare antigen-negative RBCs with potential for immunohematology applications.
• Highlighted improvement in antibody identification against high-prevalence antigens using the developed RBCs.