What question did this study set out to answer?

The aim is to investigate how dual 2B4.4-1BB signaling enhances the effectiveness of HER2-CAR NK-92 cells against ADCC-resistant tumors.

April 28, 2026Open Access

Breaking the barrier: Synergistic 2B4.4-1BB signaling potentiates HER2-CAR NK cells to penetrate and destroy ADCC-resistant tumors

Key Points

The aim is to investigate how dual 2B4.4-1BB signaling enhances the effectiveness of HER2-CAR NK-92 cells against ADCC-resistant tumors.
Reprogramming of HER2-CAR NK-92 cells through dual 2B4.4-1BB signaling.
Evaluation of tumor infiltration capabilities in ADCC-resistant tumor spheroids.
Assessment of tumor remission duration after therapy.
Dual signaling led to significant tumor infiltration and superior antitumor activity.
Achieved long-lasting tumor remission in treated tumor models.
Next-generation CAR-NK design effectively overcame immune resistance.

Abstract

• Dual 2B4·4-1BB signaling reprograms HER2-CAR NK-92 cells for durable antitumor power • Synergistic costimulation drives deep infiltration of mAbs resistant tumor spheroids • Dual 2B4·4-1BB CAR NK-92 therapy achieves long-lasting tumor remission • This next-generation CAR-NK design overcomes immune and TME derived resistance

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Cite This Study

Gergely et al. (Wed,) studied this question.

synapsesocial.com/papers/69f04e08727298f751e72085 https://doi.org/https://doi.org/10.1016/j.canlet.2026.218534

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