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March 1, 2005Journal of Clinical Investigation1,301 citations

Oxygen, oxidative stress, hypoxia, and heart failure

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FGFrank J. Giordano

Key Points

  • To evaluate the complex roles of oxygen availability, reactive oxygen species formation, and hypoxia in regulating cardiac gene expression and mediating heart failure pathogenesis.
  • Narrative synthesis of the physiological necessity of myocardial oxygenation and its role in cellular signaling pathways.
  • Review of oxygen-mediated mechanisms, including reactive oxygen species generation, gene expression regulation, and cardiac dysfunction.
  • Oxygen supply is essential for baseline cardiac function and survival but concurrently facilitates the generation of reactive oxygen species that induce cellular damage and death.
  • Fluctuations in myocardial oxygen levels directly alter cardiac gene expression networks, driving pathological remodeling and the progression of heart failure.

Abstract

A constant supply of oxygen is indispensable for cardiac viability and function. However, the role of oxygen and oxygen-associated processes in the heart is complex, and they and can be either beneficial or contribute to cardiac dysfunction and death. As oxygen is a major determinant of cardiac gene expression, and a critical participant in the formation of ROS and numerous other cellular processes, consideration of its role in the heart is essential in understanding the pathogenesis of cardiac dysfunction.

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Cite This Study

Frank J. Giordano (2005) studied this question.

synapsesocial.com/papers/69f14bfac0d8017361865b92https://doi.org/10.1172/jci24408
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