Metformin Hydrochloride has a short half-life, requiring multiple administrations to achieve the maintained control of type 2 Diabetes Mellitus. This may affect adherence to your medication regimen. The goal of this project was to create and optimize matrix tablets made with Metformin Hydrochloride using a sustained-release mechanism with a natural polymer system. To achieve this objective, Fenugreek Gum was chosen as the matrix-forming component and was used to create matrices with other excipients to make the product formulations. To evaluate these formulations, experiments were performed according to the Box–Behnken Method. The studies conducted were used to evaluate how the formulation components of Metformin Hydrochloride matrix tablets (including matrix particle size) affect the overall characteristics of the tablets (hardness, friability, weight variation, and drug content uniformity) as well as the dissolution profile. Statistical tools were used to analyze the data obtained from the experimental treatments to generate a second-order polynomial model for the response variables tested. This research provides an organized method of evaluating the formulation of sustained release dosage forms made using natural polymer materials and how these variables affect the formulation outcome.
Mourya et al. (Thu,) studied this question.