History of cardiac insufficiency, persistent AF, and platelet/lymphocyte ratio were independent risk factors for acute ischemic stroke within 1 year after RFCA (combined AUC 0.852).
Cohort (n=498)
No
What are the independent risk factors for acute ischemic stroke within 1 year after radiofrequency catheter ablation in patients with atrial fibrillation?
History of cardiac insufficiency, persistent AF, and platelet/lymphocyte ratio are independent predictors of acute ischemic stroke within 1 year following radiofrequency ablation for atrial fibrillation.
Effect estimate: Combined AUC 0.852 (95% CI 0.798-0.905)
p-value: p=<0.05
Objective To explore the risk factors for acute ischemic stroke (AIS) in patients with atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA). Methods A total of 498 patients with AF who underwent RFCA treatment at the Second Affiliated Hospital of Zhejiang University School of Medicine from June 2022 to June 2024 and had 1-year follow-up data were retrospectively selected as the research subjects. The patients were divided into the Non-AIS group ( n = 450) and the AIS group ( n = 48) based on whether AIS occurred during the follow-up period. General and clinical data of the patients were collected. Logistic regression was used to analyze the risk factors for AIS following RFCA in AF patients, and the regression model was validated. Results There were no statistically significant differences in general information between the Non-AIS group and the AIS group ( P 0.05); there were statistically significant differences in the incidence of history of cardiac insufficiency (CI), types of AF, and platelet/lymphocyte ratio (PLR) between the Non-AIS group and the AIS group ( P 0.05). The forest plot of the multivariate Logistic regression model showed that history of CI, persistent AF, and PLR were independent risk factors for AIS after RFCA within 1 year ( P 0.05). The individual and combined areas under the curve were 0.817 (0.756–0.879), 0.579 (0.486–0.673), 0.644 (0.565–0.724), and 0.852 (0.798–0.905), respectively. The cut-off value, sensitivity, and specificity of the combined receiver operating characteristic (ROC) curve were 0.287, 0.813, and 0.758, respectively. The calibration curve and clinical decision curve showed that the Logistic regression model had good accuracy. Conclusion The overall incidence of AIS within 1 year after RFCA in patients with AF is relatively low (9.64%). History of CI, persistent AF, and PLR are independent risk factors for AIS after RFCA within 1 year. Preoperative screening and strict control of indications can help reduce the occurrence of AIS after RFCA.
Wen et al. (Wed,) conducted a cohort in Atrial fibrillation (n=498). Radiofrequency catheter ablation was evaluated on Acute ischemic stroke within 1 year (Combined AUC 0.852, 95% CI 0.798-0.905, p=<0.05). History of cardiac insufficiency, persistent AF, and platelet/lymphocyte ratio were independent risk factors for acute ischemic stroke within 1 year after RFCA (combined AUC 0.852).