Does obstructive sleep apnea hypopnea syndrome (OSAHS) increase blood pressure and CRP in male patients with newly diagnosed hypertension?
Moderate to severe OSAHS in newly diagnosed hypertensive men is associated with increased nocturnal blood pressure, blunted nocturnal dipping, and elevated systemic inflammation (hs-CRP).
BACKGROUND: The influences of obstructive sleep apnea hypopnea syndrome (OSAHS) on blood pressure and C-reactive protein (CRP) were observed, and the underlying mechanism was investigated. METHODS: Respiratory sleep monitoring was performed on 188 male patients who were newly diagnosed with hypertension. Based on the apnea hypopnea index (AHI) results, patients were divided into a normal control group (AHI ≤ 5, n = 35), a mild OSAHS group (5 30, n = 68). Ambulatory blood pressure monitoring was conducted on patients in each group, and blood samples were collected to detect indicators, including fasting blood glucose (FBG), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and high-sensitivity CRP (hs-CRP). RESULTS: TG and hs-CRP in patients in the moderate and severe OSAHS groups were higher than those in the normal control group (P < 0.01, P < 0.05). Additionally, their mean nocturnal systolic blood pressure (nSBP) and nocturnal diastolic blood pressure (nDBP) were higher than those in the normal control group (P < 0.01, P < 0.05). However, the percentage of blood pressure reduction at night was significantly lower than that in the normal control group (P < 0.01). AHI and hs-CRP positively correlated with nSBP (adjusted R(2) = 0.46) and nDBP (adjusted R(2) = 0.38) and negatively correlated with the nocturnal blood pressure reduction percentage (adjusted R(2) = 0.48). CONCLUSION: Moderate and severe OSAHS induced increases in nocturnal blood pressure and CRP content in the body, resulting in further damage to the circadian rhythms of blood pressure.
Fan et al. (Fri,) studied this question.