Brodie’s abscess represents a localized, indolent form of subacute osteomyelitis typically affecting the metaphyseal region of long bones. Lesions of substantial size may create structural instability requiring staged reconstruction. We report a 28-year-old male with a large proximal tibial Brodie’s abscess treated with a two-stage strategy: (1) open curettage with insertion of vancomycin-and gentamicin-loaded polymethyl methacrylate (PMMA) beads for infection suppression, followed by (2) sandwich cancellous autografting combined with hydroxyapatite and lateral locking plate augmentation after infection control. Complete resolution of infection, progressive graft incorporation, restoration of pain-free function, and return to full weight-bearing were achieved by 8–12 weeks. For large metaphyseal Brodie’s abscesses, a staged protocol integrating dead-space management, targeted antibiotic delivery, biological reconstruction, and mechanical stabilization ensures predictable infection control and structural healing.
Arun. et al. (Thu,) studied this question.