What question did this study set out to answer?

This research aims to explore the genetic factors and pathways involved in bile acid regulation and intrahepatic cholestasis of pregnancy.

May 6, 2026

Shared and Distinct Genetic Factors Underlying Bile Acid Regulation and Intrahepatic Cholestasis of Pregnancy

Key Points

This research aims to explore the genetic factors and pathways involved in bile acid regulation and intrahepatic cholestasis of pregnancy.
Pathway analysis of bile acid synthesis and metabolism
Integrative single-cell RNA sequencing (scRNA-seq)
Mendelian randomization (MR) analysis of estrone on TBA levels
Identified genetic loci involved in bile acid metabolism and cholestasis
Enrichment of TBA-associated genes in hepatocytes and ICP-associated genes in neutrophils
Suggests causal effect of estrone on TBA levels

Abstract

) for ICP. Pathway analysis highlighted bile acid synthesis and metabolism pathways for TBA and immune-related pathways for ICP. Integrative scRNA-seq analysis revealed enrichment of TBA-associated genes in hepatocytes and ICP-associated genes in neutrophils. MR analysis suggested a potential causal effect of estrone on TBA levels. Our findings provide novel insights into the genetic architecture of TBA and ICP, emphasizing the roles of bile acid metabolism in hepatocytes and immune dysregulation in ICP pathogenesis. The identified genetic loci and pathways may inform future research on risk prediction and targeted therapies for ICP.

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Cite This Study

Zhang et al. (Sun,) studied this question.

synapsesocial.com/papers/69faa22704f884e66b532e32 https://doi.org/https://doi.org/10.1002/gepi.70040

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