< 0.00001; ARD, 0.88%; NND, 113). Elevated risks were observed with tepotinib, savolitinib, amivantamab, and rilotumumab. Notably, monoclonal antibodies carried a higher edema risk than tyrosine kinase inhibitors, and combination therapy showed greater risk than monotherapy. The risk was also higher in lung cancer and in first-line settings. These findings provide comprehensive evidence for the risk profile of peripheral edema and support individualized monitoring in clinical practice.
Jing et al. (Sun,) studied this question.