Background and objective: Helicobacter pylori infection is a leading cause of chronic gastritis and gastric cancer worldwide. Despite its clinical importance, epidemiological data from Yemen remain scarce. This study aimed to determine the prevalence and demographic distribution of H. pylori infection across three age groups and gender among patients attending the Medical City Complex in Ibb, Yemen, between August 2018 and February 2026. Methods: This cross-sectional study analyzed anonymized medical records of 18,606 patients presenting with abdominal pain who underwent the H. pylori Ag rapid test of stool. Frequencies, chi-square tests, and OR with 95% confidence intervals assessing associations between infection status and demographic variables were recorded. Results: Overall prevalence was 29.4% (n = 5,464). Females showed a higher prevalence (30.4%) than males (26.7%) with a statistically significant difference (χ² = 24.5, df = 1, p 50 years (24.4%). The association between age category and infection status was highly significant (χ² = 159.4, df = 2, p < 0.001). Conclusion: An H. pylori infection remains highly prevalent in Yemen, with significant variation across age and gender. The elevated burden among younger individuals and females underscores the need for targeted screening and preventive strategies. Given its established role in chronic gastritis and gastric cancer, these findings highlight the importance of early detection and public health interventions tailored to demographic risk profiles.
Al-Hetar et al. (Mon,) studied this question.