Using Well-Defined DNA Nanostructures To Study the Influence of DNA Clustering and Presentation on SNA Cellular Uptake

Key Points

• To investigate how DNA clustering and presentation affect the cellular uptake of DNA nanostructures.
• Utilized well-defined DNA nanostructures to study cellular uptake.
• Manipulated structural components of SNA shells for optimal performance.
• Analyzed binding interactions with proteins.
• Found that structural changes in SNA shells influence their biological function.
• Demonstrated the control of cellular uptake through DNA presentation methods.