= 27.664 ± 0.238 µg/mL) emerging as the most active analogues. Complementary antioxidant assays further underscored the multifunctional character of these scaffolds. Molecular docking studies provided mechanistic support for the experimental findings, revealing favorable binding modes within the AChE active site. Collectively, this work establishes 1,2,3-triazole-thiophene hybrids as a versatile and previously underexplored scaffold for dual-target drug design. The identified lead compounds (2c-2e) demonstrate compelling potential for further optimization toward integrated therapeutic strategies against antibiotic-resistant infections and neurodegenerative disorders.
Mehmet Erşatır (Tue,) studied this question.