Stereoreversed C–O Activation Unlocks All-Carbon Tetrasubstituted Z -Alkene Synthesis

Key Points

• To explore the potential of stereoreversed C–O activation for synthesizing all-carbon tetrasubstituted Z-alkenes.
• Investigation of C–O activation techniques
• Synthesis of Z-alkenes with high stereocontrol
• Assessment of yield in drug-related molecular synthesis.
• Achieved high-yield synthesis of tetrasubstituted Z-alkenes
• Showed effective stereocontrol during synthesis
• Indicated promising applications in drug-discovery and medicinal chemistry.