What question did this study set out to answer?

The aim is to determine the association between serum microRNA-122 levels and treatment response to diet and exercise therapy in patients with steatotic liver disease.

May 7, 2026Open Access

Serum microRNA-122 Is Associated with the Therapeutic Response to Diet and Exercise Therapy in Patients with Steatotic Liver Disease

Key Points

The aim is to determine the association between serum microRNA-122 levels and treatment response to diet and exercise therapy in patients with steatotic liver disease.
Assessment of serum microRNA-122 levels in patients undergoing lifestyle interventions.
Evaluation of treatment responses based on dietary and exercise modifications.
Higher levels of serum microRNA-122 are associated with improved therapeutic responses to lifestyle interventions.
Establishment of microRNA-122 as a potential biomarker for tracking treatment effectiveness in steatotic liver disease.

Abstract

Objective Steatotic liver disease (SLD) is a prevalent chronic liver disease for which lifestyle intervention remains the first-line treatment. However, reliable biomarkers that reflect treatment responsiveness are limited. MicroRNA-122 (miR-122) is a liver-specific microRNA involved in hepatic lipid metabolism and injury. However, its clinical significance during lifestyle intervention has not yet been fully elucidated.

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