Introduction Ageing, sedentary behaviour and/or poor nutrition contribute to increased vulnerability to chronic disease, frailty and loss of independence. An ageing population places greater demands on healthcare systems; thus highlighting the need for accessible, intrinsically motivating and scalable strategies to promote healthy ageing. This study investigated the efficacy of ‘AgeWell Europe’, an 8-week online and on-demand structured multimodal exercise programme designed specifically for middle-aged (MAA) and older-aged adults (OAA). Methods 167 participants were recruited in four countries. Balance (45-second eyes open balance test), lower-body and upper-body muscular endurance (sit-to-stand test (STS) and press-up test, respectively), cardiorespiratory fitness (6-minute walk test (6MWT)), muscular strength ( maximal voluntary contraction (MVC) for knee flexion and extension) and vertical jump were assessed pre and post intervention. Physical activity (PA) level (M1 question), wellbeing (WHO-5 Index) and physical self-efficacy (LIVAS) were examined using online questionnaires. Results A total of 121 participants completed the intervention. The age-group analysis (all MAA and OAA) identified significant improvements in STS, press-up and 6MWT performance (p 0.05). The sex based analyses revealed significant group-by-time interactions for STS (F = 5.62, p = 0.02) and 6MWT (F = 5.72, p = 0.02), with greater improvements in males than females, while both sexes significantly improvement their press-up scores (p
McDonnell et al. (Sat,) studied this question.