Abstract Background: Ulcerative colitis (UC) is an inflammatory bowel disease that is restricted to the large intestine, characterized by superficial ulceration. The inflammation extends proximally in a contiguous manner, resulting in ulcerations, severe bleeding, toxic megacolon, and fulminant colitis. Its etiology remains unknown, and it is suggested that environmental factors influence genetically susceptible individuals, leading to the onset of the disease. CXCL13 also called B cell-attracting chemokine 1(BCA-1) it’s specifically attracted B cells to inflamed site, and it’s produced by Macrophages, dendritic cells and B cells. CXCL13 regulates immune response, and fibrosis in addition to the regulation of cell proliferation and apoptosis. Objectives: This study aims to assess the clinical significance of serum chemokine (C-X-C motif) ligand 13 as a potential diagnostic marker for identifying UC in adults. Materials and Methods: A case–control study was conducted with a sample size of 50 participants in the patient group and 50 healthy individuals in the control group. Results: This study identified a highly statistically significant difference between the patient group and the control group, indicating a very good diagnostic value for identifying UC. Conclusion: The outcomes of this study suggest that serum chemokine (C-X-C motif) ligand 13 can be employed as a diagnostic marker for identifying UC. It could be used as a tool for measuring disease activity in addition to the possibility of using it as a potential therapeutic target.
Qusay et al. (Thu,) studied this question.