Does hypertension status modify the association between admission lipoprotein (a) and all-cause mortality in patients with acute decompensated heart failure?
Elevated admission lipoprotein (a) is associated with increased all-cause mortality specifically in acute decompensated heart failure patients who have concurrent hypertension.
Background and aims: Serum lipoprotein(a) Lp(a) is recognized as an independent risk factor for cardiovascular disease. However, whether hypertension modifies the association between Lp(a) and adverse outcomes in acute decompensated heart failure (ADHF) remains unclear. We investigated how hypertension status influences the relationship between Lp(a) and all-cause mortality in ADHF. Methods: We conducted a single-center retrospective observational study including 2610 patients hospitalized with ADHF. We normalized the distribution of Lp(a) by a logarithmic transformation and assessed the risk of all-cause mortality with Lp(a), using Cox regression with adjustment for potential confounders. Results: = 0.002). Conclusions: Increased admission Lp(a) levels were associated with a higher risk of all-cause mortality in ADHF patients with hypertension. Further studies are needed to explore the mechanistic links among Lp(a), hypertension and ADHF.
Vidanage et al. (Sat,) studied this question.
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