In silico strategy for bio-resilience against orthopoxvirus: integration of trained immunity and multi-layer pharmacological inhibition

Key Points

• This research aims to develop an in silico strategy to enhance resilience against orthopoxvirus by integrating trained immunity and pharmacological approaches.
• In silico modeling of immune responses to orthopoxvirus.
• Integration of pharmacological inhibition techniques.
• Characterization and assessment of bio-resilience mechanisms.
• Demonstrated increased efficacy in combating orthopoxvirus infections.
• Observed enhanced immune response through trained immunity.
• Identified multi-layered inhibition pathways contributing to resilience.