What question did this study set out to answer?

To assess the prevalence of psychiatric disorders in Hispanic patients with inflammatory bowel disease (IBD) and their clinical correlates.

May 9, 2026Cureus0 citationsOpen Access

Prevalence and Clinical Correlates of Psychiatric Disorders in a Hispanic-Majority Inflammatory Bowel Disease Cohort

MOMatthew OrosaRiverside University Health System - Medical Center MXMindy XuRiverside University Health System - Medical Center ACAndrew ChangLoma Linda University

Key Points

To assess the prevalence of psychiatric disorders in Hispanic patients with inflammatory bowel disease (IBD) and their clinical correlates.
Conducted a single-center, retrospective cohort study from 2015 to 2024
Analyzed demographic and clinical variables in 158 adult patients with IBD
Used Mann-Whitney U, chi-square, and multivariable logistic regression for associations.
Prevalence of at least one psychiatric disorder was 48.7%
Common diagnoses included depression and anxiety (30.4% each) and insomnia (26.6%)
IBD-related hospitalization associated with psychiatric comorbidity (54.5% vs. 30.9%, p=0.004).

Abstract

Introduction: Inflammatory bowel disease (IBD) is a chronic immune-mediated condition associated with a substantial burden of psychiatric comorbidity. Depression, anxiety, and other psychiatric disorders are increasingly recognized as important contributors to disease activity, healthcare utilization, and quality of life. However, existing data are largely derived from tertiary care populations, with limited representation of underserved and Hispanic patients. Methods: We conducted a single-center, retrospective cohort study of adult patients with IBD within a county health system from 2015 to 2024. The primary outcome was the presence of at least one psychiatric disorder, defined as depression, anxiety, post-traumatic stress disorder, bipolar disorder, psychotic disorders, substance use disorders, or insomnia. Demographic and clinical variables, including age, sex, IBD type, smoking status, and IBD-related hospitalization, were analyzed. Associations were evaluated using Mann-Whitney U testing, chi-square testing, and multivariable logistic regression. Results: A total of 158 patients met the inclusion criteria. The prevalence of at least one psychiatric disorder was 48.7%. Depression and anxiety were the most common diagnoses (30.4% each), followed by insomnia (26.6%). The IBD-related hospitalization was significantly associated with psychiatric comorbidity in univariate analysis (54.5% vs. 30.9%, p=0.004). In multivariable analysis, hospitalization was associated with numerically increased odds that did not reach conventional statistical significance (OR 2.32, 95% CI 0.98-5.50, p=0.056). Conclusions: Psychiatric disorders are highly prevalent among IBD patients in a county health system, affecting nearly half of the cohort. The IBD-related hospitalization was associated with psychiatric comorbidity in univariate analysis and showed a non-significant trend in multivariable analysis. The results point to the value of coordinated, team-based care models tailored to the needs of underserved communities.

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