Adsorption-catalysis Integrated Au@ZIF-8 for Structural Detoxification and Trace Detection of Nitro Impurities

Key Points

• The aim is to develop an effective method for detoxifying nitro-containing impurities in pharmaceuticals.
• Utilized an integrated Au@ZIF-8 system for the detoxification process.
• Conducted trace detection of nitro impurities post-treatment.
• Evaluated the safety implications in pharmaceutical applications.
• The Au@ZIF-8 system effectively reduced nitro impurity levels, achieving over 90% detoxification rate.
• Significant decrease in oxidative toxicity observed in treated samples.
• Trace detection limits improved, enhancing safety profiling for pharmaceutical formulations.