January 5, 2009Organic Letters186 citations

Instantaneous Deprotection of Tosylamides and Esters with SmI2/Amine/Water

TATobias AnknerRISE Research Institutes of Sweden GHGöran HilmerssonUniversity of Gothenburg

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Abstract

SmI(2)/amine/water mediates instantaneous cleavage of tosyl amides and tosyl esters. Highly hindered, sensitive and functionalized substrates were successfully deprotected in near quantitative yield.

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Ankner et al. (Mon,) studied this question.

synapsesocial.com/papers/6a00e565e4618ba4162dc4ac https://doi.org/https://doi.org/10.1021/ol802243d

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