May 1, 2022Open Access

LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity

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Abstract

and sodium butyrate promote host immunity by enhancing endogenous LL-37 expression and its mediated cGAMP immune response. Collectively, our data uncover an essential role of LL-37 in innate immune activation and suggest new strategies for immunotherapy.

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Wei et al. (Sun,) studied this question.

synapsesocial.com/papers/6a01f94d0cec8eebbd5cb96f https://doi.org/https://doi.org/10.1016/j.celrep.2022.110880

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4STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling2008 · 3,490 citations
5FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.1995 · 502 citations

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