What question did this study set out to answer?

The study evaluates the accuracy of the BREATH2 score for diagnosing heart failure with preserved ejection fraction (HFpEF).

May 11, 2026

Screening for heart failure with preserved ejection fraction using the BREATH2 score: diagnostic performance and prognostic value

Key Points

The study evaluates the accuracy of the BREATH2 score for diagnosing heart failure with preserved ejection fraction (HFpEF).
Retrospective, single-center study with 234 patients aged 73 years on average.

Structured PICO

Does the BREATH2 score accurately diagnose HFpEF in patients with LVEF ≥ 50%?

Population

234 patients with a left ventricular ejection fraction ≥ 50%, median age 73 years, 25.6% female.

Intervention

BREATH2 score

Comparator

HFA-PEFF algorithm (reference standard)

Outcome

Diagnostic utility and prognostic value of the BREATH2 score

The BREATH2 score may have utility in screening for HFpEF in patients with LVEF ≥ 50%, though full results are truncated in the abstract.

Abstract

BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is more prevalent in aging societies and remains challenging to diagnose in primary care. The BREATH OBJECTIVES: This study aimed to evaluate the diagnostic utility of the BREATH METHODS: This retrospective, single-center study examined 234 patients (median age 73 years; 25.6% female) with a left ventricular ejection fraction ≥ 50%. HFpEF was diagnosed using the HFA-PEFF algorithm. The BREATH RESULTS: HFpEF prevalence rose progressively with the BREATH CONCLUSIONS: The BREATH

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Cite This Study

Kinoshita et al. (Sat,) studied this question.

synapsesocial.com/papers/6a025efac9581ed855361b1b https://doi.org/https://doi.org/10.1016/j.hrtlng.2026.102832

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