Patients with psychiatric disorders had an increased risk of developing cardiovascular risk factors, especially diabetes (HR 2.42; 95% CI 2.20-2.67) and hyperlipidemia (HR 1.78; 95% CI 1.60-1.97).
Cohort (n=524,952)
Yes
Does a diagnosis of psychiatric disorders increase the risk of developing cardiovascular risk factors in adults aged ≥30?
Patients with psychiatric disorders have a significantly higher risk of developing cardiovascular risk factors, particularly diabetes and hyperlipidemia, which are often detected later than in the general population.
Effect estimate: HR 2.42 (95% CI 2.20-2.67)
BACKGROUND: The evidence informing the management of cardiovascular risk in patients with psychiatric disorders is weak. METHODS: This cohort study used data from all patients, aged≥30, registered in 140 primary care practices (n=524,952) in London to estimate the risk of developing diabetes, hypertension, hyperlipidemia, tobacco consumption, obesity, and physical inactivity, between 2005 and 2015, for patients with a previous diagnosis of schizophrenia, depression, anxiety, bipolar or personality disorder. The role of antidepressants, antipsychotics and social deprivation in these associations was also investigated. The age at detection of cardiovascular risk factor was compared between patients with and without psychiatric disorders. Variables, for exposures and outcomes, defined from general practitioners records, were analysed using multivariate regression. RESULTS: Patients with psychiatric disorders had an increased risk for cardiovascular risk factors, especially diabetes, with hazard ratios: 2.42 (2.20-2.67) to 1.31 (1.25-1.37), hyperlipidemia, with hazard ratios: 1.78 (1.60-1.97) to 1.25 (1.23-1.28), and obesity. Antidepressants, antipsychotics and social deprivation did not change these associations, except for smoking and physical inactivity. Antidepressants were associated with higher risk of diabetes, hypertension and hyperlipidemia. Antipsychotics were associated with a higher risk of diabetes. Antidepressants and antipsychotics were associated with lower risk of other risk factors. Patients with psychiatric conditions have later detection of cardiovascular risk factors. The interpretation of these results should acknowledge the lower rates of detection of risk factors in mentally ill patients. CONCLUSIONS: Cardiovascular risk factors require special clinical attention among patients with psychiatric disorders. Further research could study the effect of antidepressants and antipsychotics on cardiovascular risk factors.
Pérez-Piñar et al. (2016) conducted a cohort in Psychiatric disorders (n=524,952). Psychiatric disorders vs. Patients without psychiatric disorders was evaluated on Risk of developing diabetes, hypertension, hyperlipidemia, tobacco consumption, obesity, and physical inactivity (HR 2.42, 95% CI 2.20-2.67). Patients with psychiatric disorders had an increased risk of developing cardiovascular risk factors, especially diabetes (HR 2.42; 95% CI 2.20-2.67) and hyperlipidemia (HR 1.78; 95% CI 1.60-1.97).