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May 14, 2026Journal of the American College of Cardiology

Stress cardiomyopathy links to higher mortality versus the general population, mostly within the first year.

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Why the study?

Stress cardiomyopathy is a recently recognized condition, and this study aimed to define more completely its clinical spectrum and consequences beyond the acute event.

Population

136 consecutive SC patients

Design

Prospective cohort study

Key result

Stress cardiomyopathy was associated with higher all-cause mortality during follow-up compared to a matched general population (p = 0.016), with most deaths occurring in the first year.

Authors

SSScott W. SharkeyDWDenise WindenburgJLJohn R. Lesser

Discussion

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Overview

Defines long-term consequences of stress cardiomyopathy; leaves open evidence-based strategies for recurrence prevention.

Key Points

  • This research aims to comprehensively outline the clinical spectrum and outcomes of stress cardiomyopathy beyond the initial event.
  • Prospective assessment of clinical profiles and outcomes in 136 consecutive patients with stress cardiomyopathy.
  • Patient demographics included predominantly women, aged 32 to 94 years, with varying stress triggers.
  • Utilized cardiovascular magnetic resonance imaging to classify ventricular contraction patterns.
  • Identified a diverse clinical profile with significant noncardiac mortality (p = 0.016) during follow-up.
  • Notable findings included 18% of patients on beta-blockers not being absolutely protected from stress cardiomyopathy events.
  • Five patients had right and/or left ventricular thrombi identified, with two associated embolic events.

Study Design

Type

Cohort (n=136)

Structured PICO

P
Population
136 consecutive patients with stress cardiomyopathy (SC), mean age 68 +/- 13 years, 96% women.
C
Comparator
Matched general population
O
Outcome
Clinical profile and outcomes including mortality, recurrence, and ventricular contraction patternshard clinical

Main Result

p-value: p=0.016

Stress cardiomyopathy has a heterogeneous clinical spectrum and is associated with increased all-cause mortality compared to a matched general population.

Cite This Study

Sharkey et al. (2010) conducted a cohort in Stress (Tako-Tsubo) Cardiomyopathy (n=136). Stress cardiomyopathy was associated with higher all-cause mortality during follow-up compared to a matched general population (p = 0.016), with most deaths occurring in the first year.

synapsesocial.com/papers/6a053f25874cea25422d70b4https://doi.org/10.1016/j.jacc.2009.08.057
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