What question did this study set out to answer?

The research aims to explore the association between co-infection by adeno-associated virus type 2 and human adenovirus type 41 and acute severe hepatitis in children.

May 15, 2026Open Access

Adeno-Associated Virus Type 2 and Human Adenovirus Species F Type 41 Co-infection Associated with Acute Severe Hepatitis in Children, California, USA

Key Points

The research aims to explore the association between co-infection by adeno-associated virus type 2 and human adenovirus type 41 and acute severe hepatitis in children.
Case report involving pediatric patients in California with acute severe hepatitis
Monitoring of clinical outcomes and need for liver transplantation
One patient required liver transplantation; both patients ultimately recovered
Findings indicate the necessity for improved physician awareness and surveillance measures

Abstract

copies/mL). One patient required liver transplantation; both patients recovered. Our findings underscore the need for heightened physician awareness and expanded surveillance to identify and characterize new cases, improve understanding of underlying pathophysiology, clarify risk factors, and inform therapeutic strategies.

Adeno-Associated Virus Type 2 and Human Adenovirus Species F Type 41 Co-infection Associated with Acute Severe Hepatitis in Children, California, USA

Key Points

Abstract

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