Pregnancy in women with solid organ transplants was associated with high complication rates, including gestational diabetes (34.8% in kidney recipients), preterm birth (56.3%), and anemia (73.8%).
Observational (n=28)
No
What are the pregnancy courses and birth outcomes in women with solid organ transplants?
Pregnancy in women with solid organ transplants is associated with high rates of maternal and fetal complications, requiring careful multidisciplinary planning and monitoring.
Objective. Analysis of pregnancy course and birth outcomes in women with transplanted organs. Material and methods. This retrospective single-center study included an examination of the course of 30 pregnancies in 28 women: 25 pregnancies after kidney transplantation (KT) in 23 patients, including two pregnancies in two patients after combined KT and pancreas transplantation (PT), and five pregnancies in five patients with (non-renal) organ transplants. Each pregnancy was considered a separate clinical observation. Among the pregnancies after non-renal transplants, two occurred after heart transplantation (HT), one after heart-lung transplantation (HLT), one after lung transplantation (LT), one after liver transplantation (LiT). Results. We present an analysis of the pregnancy course and birth outcomes in patients with solid organ transplants observed at the V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology. A high incidence of gestational diabetes mellitus (GDM) was noted in women with KT — 34.8%. In two patients after non-renal transplantation, pregnancy was complicated by the development of GDM. Almost every fourth pregnancy was complicated by the development of preeclampsia, which significantly exceeds the population level. The incidence of baseline and gestational arterial hypertension reached 47.8 and 43.5%, respectively. According to our data, the incidence of preterm birth in pregnant women with KT was 56.3%, and in two cases, preterm births occurred in patients with HT and HLT. Predictors of preterm birth in this patient category are presented. Anemia was observed in 73.8% of pregnant women with KT, and in all pregnant women with HT and HLT. Conclusion. Successful pregnancy and the birth of a healthy child are possible in women with organ transplants with careful planning and monitoring before conception, during pregnancy, and in the early postpartum period.
Kovalenko et al. (Wed,) conducted a observational in Pregnancy in women with transplanted organs (n=28). Pregnancy in organ transplant recipients was evaluated on Pregnancy course and birth outcomes (including gestational diabetes, preeclampsia, preterm birth, and anemia). Pregnancy in women with solid organ transplants was associated with high complication rates, including gestational diabetes (34.8% in kidney recipients), preterm birth (56.3%), and anemia (73.8%).