What question did this study set out to answer?

This research aims to explore the real-time conformational changes of adenosine/aptamer complexes.

May 15, 2026

Real-time Investigating Two Conformational Changes of an Adenosine Aptamer with Single-Molecule Fingerprint Signals

Key Points

This research aims to explore the real-time conformational changes of adenosine/aptamer complexes.
Utilized fingerprint signals for detection
Analyzed two conformations corresponding to kinetic and thermodynamic products
Implemented multi-parameter fingerprint-based discrimination
Identified two distinct conformational states of the adenosine/aptamer complex
Demonstrated the ability to monitor conformational changes in real-time
Showed differentiation based on kinetic versus thermodynamic characteristics

Abstract

By utilizing fingersprint signanls, the conformation changes of Adenosine/aptamer complex were investigated in real time. Two conformations correspond to the kinetic and thermodynamic products respectively. Furthermore, a multi-parameter fingerprint-based discrimination...

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Cite This Study

Zhong et al. (Thu,) studied this question.

synapsesocial.com/papers/6a06b95be7dec685947abed2 https://doi.org/https://doi.org/10.1039/d6cc02317g

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