This article examines the pharmacological aspects of drug administration during pregnancy and lactation. Special attention is paid to physiological changes occurring in the maternal organism, pharmacokinetic and pharmacodynamic alterations of medications, placental drug transfer mechanisms, fetal risks associated with teratogenicity, and the safety of medicines during breastfeeding. Evidence-based approaches for evaluating the risk-benefit ratio of pharmacotherapy in pregnant and lactating women are discussed. The article also analyzes international recommendations concerning the rational and safe use of drugs in obstetric and neonatal practice. Current scientific findings demonstrate that inappropriate medication use during pregnancy may lead to congenital malformations, fetal toxicity, developmental disorders, and neonatal complications, while rational pharmacotherapy significantly improves maternal and fetal outcomes. The study emphasizes the importance of individualized pharmacological management, evidence-based prescribing, and careful monitoring during pregnancy and lactation.
Gulnozakhon Mukhidin kizi Ruzimatova (Wed,) studied this question.