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A chiral cyclopentadienyl (Cpx) ligand featuring the semi-saturated H8-binaphthyl backbone as the chiral element was developed. Its application potential was demonstrated by CpxRhIII-catalyzed C–H bond functionalization of acryl acids and allenes, exhibiting superior catalytic performance compared to other Cpx ligands. The outlined enantioselective 4 + 1-annulation process results in synthetically attractive α,β-unsaturated γ-lactones having an allylic stereogenic center, which were obtained in enantioselectivities of up to 99:1 enantiomeric ratio.
Wang et al. (Mon,) studied this question.