SCN5A variants are causatively associated with various inherited cardiac channelopathies and structural heart diseases, including Brugada syndrome, long QT syndrome, and dilated cardiomyopathy.
-related cardiac disorders and the newly developed therapy strategies potentially useful to prevent and treat these disorders in clinical setting.
Li et al. (2018) conducted a review in SCN5A-related cardiac disorders. SCN5A variants are causatively associated with various inherited cardiac channelopathies and structural heart diseases, including Brugada syndrome, long QT syndrome, and dilated cardiomyopathy.