Experimental and clinical evidence supports the role of hypercontractility and cellular energy alterations in the progression of hypertrophic cardiomyopathy towards heart failure and sudden cardiac death.
Hypercontractility and cellular energy alterations play a key role in the progression of hypertrophic cardiomyopathy towards heart failure and sudden cardiac death.
-buffering of the myofilaments and changes in the ATP/ADP ratio. Understanding the mechanisms driving the progression of HCM is critical to the development of effective therapeutic strategies. This paper presents evidence from both experimental and clinical studies that support the role of hypercontractility and cellular energy alterations in the progression of HCM towards heart failure and sudden cardiac death.
Sequeira et al. (Sat,) conducted a review in Hypertrophic cardiomyopathy. Experimental and clinical evidence supports the role of hypercontractility and cellular energy alterations in the progression of hypertrophic cardiomyopathy towards heart failure and sudden cardiac death.