The aim of this study was to characterize the ultrastructural organization of endothelial cells in the cerebellar cortex capillaries of the domestic bull. Investigation of cerebellar endotheliocytes is of considerable interest for both fundamental science and applied veterinary medicine and neurobiology, as these cells play a central role in regulating microcirculation and metabolism mechanisms. A clearer understanding of their ultrastructure may contribute to the development of new methods for diagnostics and treatment. Fragments of cerebellar cortex tissues were processed using standard methods, and were studied using electron microscopy. The terminology was described in accordance with the International Histological Nomenclature. The analysis demonstrated that the endotheliocytes of the cerebellar cortex capillaries of the domestic bull represent the primary structural component of the blood-brain barrier. They form the capillary lumen, are intercontacted by well-developed tight junctions, and rest upon a continuous basal membrane. The continuity of the latter and the presence of tight junctions restricts the possibility of spontaneous transport of macromolecular compounds from the bloodstream to the brain tissue.
Prusakov et al. (Thu,) studied this question.