What question did this study set out to answer?

The aim is to develop a sustainable method for synthesizing chiral 2,3-dihydroxy aryl ketones.

May 16, 2026Green Chemistry0 citations

Enantiocomplementary Synthesis of Chiral 2,3-Dihydroxy Aryl Ketones via ThDP-Dependent Enzymatic Catalysis

DLDan LiJiangnan University ZZZheng ZhuEast China University of Science and Technology XCXiaoyu ChenCentral South University

Key Points

The aim is to develop a sustainable method for synthesizing chiral 2,3-dihydroxy aryl ketones.
Utilized ThDP-dependent enzymes for biocatalysis.
Coupled aryl aldehydes with unprotected glycolaldehyde.
Successfully synthesized various chiral 2,3-dihydroxy aryl ketones.
Demonstrated high enantiomeric excess in products.

Abstract

A green and enantiocomplementary biocatalytic platform for chiral 2,3-dihydroxy aryl ketones has been developed. This method employs ThDP-dependent enzymes to catalyze the direct coupling of aryl aldehydes with unprotected glycolaldehyde...

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