What question did this study set out to answer?

This research investigates the antiviral effects of remdesivir and favipiravir on poliovirus.

May 16, 2026

Remdesivir and Favipiravir as Potential Antivirals for Poliovirus: In Vitro Efficacy and RNA-dependent RNA polymerase Binding Analysis

Key Points

This research investigates the antiviral effects of remdesivir and favipiravir on poliovirus.
In vitro experiments assessing the efficacy of remdesivir and favipiravir against poliovirus.

Structured PICO

Population

HeLa cells infected with Sabin-like poliovirus types 1 (SL1) and 3 (SL3)

Intervention

Remdesivir, Favipiravir, and Ribavirin individually and in combination

Outcome

Antiviral effects measured by cytopathic effect inhibition, MTT assay, and qRT-PCR, and RdRp binding affinitysurrogate

Remdesivir, Favipiravir, and Ribavirin show potential in vitro antiviral activity against poliovirus.

Abstract

Complete poliovirus eradication requires managing chronic excreters and controlling potential outbreaks. RNA-dependent RNA Polymerase (RdRp) inhibitors represent promising candidates for this purpose. The antiviral activities of Remdesivir, Favipiravir, and Ribavirin against Sabin-like poliovirus types 1 (SL1) and 3 (SL3) were evaluated in HeLa cells individually and in combination. Antiviral effects were measured by cytopathic effect inhibition, MTT assay, and qRT-PCR. Drug-drug interactions were analyzed using Synergy Finder Plus. Molecular docking was performed to evaluate RdRp binding affinity. Remdesivir demonstrated the modest activity with low EC

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Cite This Study

Soheili et al. (Fri,) studied this question.

synapsesocial.com/papers/6a080f57a487c87a6a40db06 https://doi.org/https://doi.org/10.1016/j.virol.2026.110955

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