Higher physical activity was associated with greater left ventricular mass (e.g., 3.1 g/m2 greater in men; p<0.001) and lower resting heart rate compared with no intentional exercise.
Cross-Sectional (n=4,992)
Does higher physical activity induce physiological cardiac remodeling in a community-based population free of clinical cardiovascular disease?
In a community-based population without clinical cardiovascular disease, higher physical activity is associated with physiological cardiac remodeling, including greater left ventricular mass and end-diastolic volume, and lower resting heart rate.
p-value: p=<0.001
OBJECTIVE: To evaluate the association of physical activity with left ventricular structure and function in the general population in a community setting. DESIGN: Cross-sectional study. SETTING: The Multi-Ethnic Study of Atherosclerosis (MESA), a population-based study of subclinical atherosclerosis. PARTICIPANTS: A multiethnic sample of 4992 participants (aged 45-84 years; 52% female) free of clinically apparent cardiovascular disease. INTERVENTIONS: Physical activity induces beneficial physiological cardiac remodelling in a cross-sectional study of non-athlete individuals. MAIN OUTCOME MEASURES: Left ventricular mass, volumes and function were assessed by cardiac magnetic resonance imaging. Physical activity, defined as intentional exercise and total moderate and vigorous physical activity, was assessed by a standard semiquantitative questionnaire. RESULTS: Left ventricular mass and end-diastolic volume were positively associated with physical activity (eg, 1.4 g/m(2) (women) and 3.1 g/m(2) (men) greater left ventricular mass in the highest category of intentional exercise compared with individuals reporting no intentional exercise; p = 0.05 and p<0.001, respectively). Relationships were non-linear, with stronger positive associations at lower levels of physical activity (test for non-linearity; p = 0.02 and p = 0.03, respectively). Cardiac output and ejection fraction were unchanged with increased physical activity levels. Resting heart rate was lower in women and men with higher physical activity levels (eg, -2.6 beats/minute lower resting heart rate in the highest category of intentional exercise compared with individuals reporting no intentional exercise; p<0.001). CONCLUSIONS: In a community-based population free of clinically apparent cardiovascular disease, higher physical activity levels were associated with proportionally greater left ventricular mass and end-diastolic volume and lower resting heart rate.
Türkbey et al. (Mon,) conducted a cross-sectional in Free of clinically apparent cardiovascular disease (n=4,992). Physical activity vs. No intentional exercise was evaluated on Left ventricular mass, volumes and function (p=<0.001). Higher physical activity was associated with greater left ventricular mass (e.g., 3.1 g/m2 greater in men; p<0.001) and lower resting heart rate compared with no intentional exercise.