Inflammatory and hemostatic markers predict future cardiovascular disease risk in the elderly, though evidence is lacking for associations with ambient levels of coagulation or fibrinolytic factors.
Do hemostatic and inflammatory markers predict future cardiovascular disease risk in elderly individuals?
Inflammatory and hemostatic markers are important predictors of future cardiovascular risk in the elderly, though associations in women are complicated by hormone replacement therapy.
Inflammation has been recognized as an integral component of atherothrombotic disease, and inflammatory markers are strongly related to future cardiovascular disease risk in elderly men, and to a certain extent in elderly women. The association is complicated by the prevalence of hormone replacement therapy among older women, and the variety of the underlying vascular disease. For fatal events, inflammation markers exhibit a time-to-event dependency in the elderly that has not been noted to the same degree in younger people. Hemostatic markers that represent inflammatory processes or coagulation activation also predict future risk in older individuals, but there is little evidence for associations between cardiovascular disease risk and ambient levels of coagulation or fibrinolytic factors.
Russell P. Tracy (Fri,) conducted a review in Coronary Disease. Hemostatic and Inflammatory Markers was evaluated on Cardiovascular disease risk. Inflammatory and hemostatic markers predict future cardiovascular disease risk in the elderly, though evidence is lacking for associations with ambient levels of coagulation or fibrinolytic factors.
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