The EGSYS score accurately differentiated cardiac syncope from neurally mediated syncope in children, achieving an AUC of 0.922 with 84.3% sensitivity and 87.9% specificity at a cutoff of ≥3.
Cohort (n=332)
No
Does the EGSYS score accurately differentiate cardiac syncope from neurally mediated syncope in children?
The EGSYS score, originally designed for adults, appears to be a sensitive tool for differentiating high-risk cardiac syncope from neurally mediated syncope in pediatric patients.
Effect estimate: AUC 0.922 (95% CI 0.892-0.952)
p-value: p=<0.001
Background and objective: Syncope is a common emergency with diverse etiologies in children. Among these, cardiac syncope (CS) is associated with high mortality and is usually difficult to diagnose. However, there is still no validated clinical prediction model to distinguish CS from other forms of pediatric syncope. The Evaluation of Guidelines in Syncope Study (EGSYS) score was designed to identify CS in adults and has been validated in several studies. In this study, we aimed to assess the ability of the EGSYS score in predicting CS in children. Methods: In this retrospective study, we calculated and analyzed the EGSYS scores of 332 children hospitalized for syncope between January 2009 and December 2021. Among them, 281 were diagnosed with neurally mediated syncope (NMS) through the head-up tilt test, and 51 were diagnosed with CS using electrocardiography (ECG), echocardiography (ECHO), coronary computed tomography angiography (CTA), myocardial enzymes and genetic screening. The receiver operating characteristic (ROC) curve and Hosmer-Lemeshow test were used to evaluate the predictive value of the EGSYS score system. Results: > 0.05) of the score, indicating a good fit of the model. Conclusion: The EGSYS score appeared to be sensitive for differentiating CS from NMS in children. It might be used as an additional diagnostic tool to aid pediatricians in accurately identifying children with CS in the clinical practice.
Li et al. (Fri,) conducted a cohort in Syncope (n=332). EGSYS score was evaluated on Discrimination of cardiac syncope (Area under the ROC curve) (AUC 0.922, 95% CI 0.892-0.952, p=<0.001). The EGSYS score accurately differentiated cardiac syncope from neurally mediated syncope in children, achieving an AUC of 0.922 with 84.3% sensitivity and 87.9% specificity at a cutoff of ≥3.
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