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December 17, 1970New England Journal of Medicine95 citations

Circulatory Assistance and Emergency Direct Coronary Artery Surgery for Shock Complicating Acute Myocardial Infarction

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EMEldred D. MundthPYPeter M. YurchakMBMortimer J. Buckley

Key Result

Mechanical circulatory assistance via intra-aortic balloon pumping is an effective method for treating persistent shock complicating acute myocardial infarction, which otherwise has a 75-80% mortality.

Key Points

  • This research aims to assess the effectiveness of circulatory assistance during shock caused by acute myocardial infarction.
  • Utilized electrocardiographically synchronized balloon inflation in the descending thoracic aorta.
  • Administered vasopressor and inotropic agents for shock management.
  • Estimated mortality rates for patients unresponsive to therapy.
  • Mortality rates for patients experiencing persistent shock range from 75% to 80%.
  • Patients not responding to initial therapy face a mortality rate close to 100%.
  • Mechanical assistance demonstrated efficacy in diastolic pressure improvement.

Structured PICO

Does circulatory assistance and emergency direct coronary artery surgery improve outcomes in patients with shock complicating acute myocardial infarction?

P
Population
Patients with persistent shock complicating acute myocardial infarction failing to respond to vasopressor and inotropic agents
I
Intervention
Circulatory assistance (diastolic augmentation by intra-aortic balloon pump) and emergency direct coronary artery surgery

The text introduces the rationale for using mechanical circulatory assistance and emergency coronary surgery to treat highly fatal cardiogenic shock complicating acute myocardial infarction.

Abstract

CUMULATIVE experience has shown that the mortality of persistent shock complicating acute myocardial infarction is in the range of 75 to 80 per cent despite the prompt institution of therapy with vasopressor and inotropic agents.1 2 3 Patients who fail to respond to these therapeutic measures have a mortality of virtually 100 per cent.4 Diastolic augmentation of arterial pressure by electrocardiographically synchronized phasic inflation and deflation of a segmented balloon inserted into the descending thoracic aorta via the femoral artery has been established as an effective method of mechanical circulatory assistance. This technic has been shown to be of value as a . . .

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Cite This Study

Mundth et al. (1970) studied Shock complicating acute myocardial infarction. Mechanical circulatory assistance (intra-aortic balloon pump) and emergency direct coronary artery surgery was evaluated. Mechanical circulatory assistance via intra-aortic balloon pumping is an effective method for treating persistent shock complicating acute myocardial infarction, which otherwise has a 75-80% mortality.

synapsesocial.com/papers/6a089512ef79633196e8c2b7https://doi.org/10.1056/nejm197012172832506
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