Eight weeks of high-intensity interval training and combined training significantly reduced serum levels of CTRP3 (p=0.011) and CTRP1 (p=0.007) while improving body composition and insulin sensitivity in overweight and obese women.
RCT (n=33)
Simple method involving numbered opaque sealed envelopes
No
Does high-intensity interval training or combined training improve CTRP3 levels, insulin sensitivity, and atherogenic index of plasma in overweight and obese women?
Both high-intensity interval training and combined training effectively improve body composition, lipid profiles, glycemic control, and reduce atherogenic index and CTRP1/3 levels in overweight and obese women.
p-value: p=0.011
BACKGROUND: Obesity, defined as excessive body fat accumulation, is closely linked to an increased risk of metabolic disorders, cardiovascular diseases, and insulin resistance. This study investigates the effects of combined training (CT) and high-intensity interval training (HIIT) on insulin sensitivity, atherogenic index of plasma (AIP), and serum levels of C1q/TNF-related proteins (CTRP1 and CTRP3) in overweight and obese women. METHODS: Thirty-three overweight and obese women (aged 18-50 years) were randomly divided into three groups: control (CON, n = 10), HIIT(n = 9), and combined training (CT, n = 10). The HIIT protocol consisted of intervals performed at 100% of maximum aerobic velocity (MAV) and rest intervals at 50% of MAV, with a 30-s work-to-rest ratio. The CT sessions included RT followed by AT. RT comprised seven exercises performed in three sets of 10-16 repetitions at 60-75% of one-repetition maximum (1RM). AT involved running for 15-30 min at 60-75% of heart rate reserve. Subjects trained three times per week. Body composition, biochemical, and functional assessments were conducted 48 h before and after the interventions. RESULTS: Body mass index 1.3% and 2% (p = 0.001); TG 1.7%, 1.2% (p = 0.001);LDL 0.93%,0.83% (p = 0.012); HOMA-IR 9.5%,11.7% (p = 0.018); AST 4.2%,11.7% (p = 0.001); ALT 9.3%,10.9% (p = 0.001); 1RM 2.5%, 14.2% (p = 0.001); and maximum oxygen consumption 8%,2.4% (p = 0.001) showed significant improvements in both the HIIT and CT groups,resectively. Additionally, serum levels of CTRP 10.47%,0.34% (p = 0.007); and CTRP3 1.51%,1.53% (p = 0.011) significantly decreased in the HIIT and CT groups,resectively. CONCLUSIONS: The results suggest that HIIT and CT are effective strategies for improving body composition, lipid profile, glycemic control, liver enzyme levels, and functional capacity. Moreover, both exercise modalities were associated with reduced serum levels of the adipokines CTRP1 and CTRP3, highlighting a potential link between these biomarkers and improvements in body composition, lipid profile, glycemic control, and liver enzyme levels. TRIAL REGISTRATION: Registered retrospectively in the Iranian Registry of Clinical Trials (IRCT20241207063967 N1) on 18/01/2025. Access at https:// https://irct.behdasht.gov.ir/trial/80615 .
Shahiddoust et al. (Tue,) conducted a rct in Overweight and obesity (n=33). High-intensity interval training (HIIT) and Combined training (CT) vs. Control (no structured physical exercise) was evaluated on Serum levels of CTRP3 (p=0.011). Eight weeks of high-intensity interval training and combined training significantly reduced serum levels of CTRP3 (p=0.011) and CTRP1 (p=0.007) while improving body composition and insulin sensitivity in overweight and obese women.
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