LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease2020 · 10 citations
2. 2An Atlas on Chromosomes in Hematological Malignancies. Example: 11q23 and MLL partners2001 · 122 citations
3. 3Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes2008 · 543 citations
4. 4Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia2012 · 450 citations
5. 5Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes2013 · 209 citations