A DNA marker at the Harvey ras-1 locus was linked to long QT syndrome with a lod score of 16.44 at theta = 0, localizing the gene to the short arm of chromosome 11.
Observational
This study provides early genetic evidence localizing the gene responsible for long QT syndrome to the short arm of chromosome 11, linked to the Harvey ras-1 locus.
Effect estimate: lod score 16.44
Genetic factors contribute to heart disease. In this study, linkage analyses have been performed in a family that is predisposed to sudden death from cardiac arrhythmias, the long QT syndrome (LQT). A DNA marker at the Harvey ras-1 locus (H-ras-1) was linked to LQT with a logarithm of the likelihood ratio for linkage (lod score) of 16.44 at theta = 0, which confirms the genetic basis of this trait and localizes this gene to the short arm of chromosome 11. As no recombination was observed between LQT and H-ras-1, and there is a physiological rationale for its involvement in this disease, ras becomes a candidate for the disease locus.
Keating et al. (1991) conducted an observational in Long QT syndrome (LQT). Harvey ras-1 locus (H-ras-1) DNA marker was evaluated on Genetic linkage to LQT (lod score 16.44). A DNA marker at the Harvey ras-1 locus was linked to long QT syndrome with a lod score of 16.44 at theta = 0, localizing the gene to the short arm of chromosome 11.
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