A biophysically based computer model confirmed that cardiac wavelength must be below a critical value for atrial fibrillation to be sustained via multiple re-entrant wavelets.
Computer modeling demonstrates that accurate interpretation of cardiac wavelength in atrial fibrillation requires prior knowledge of the underlying wavelet dynamics.
Abstract Aim To explain the contradictory results related to the concept of critical cardiac wavelength in the initiation and perpetuation of atrial fibrillation (AF). Methods A biophysically based computer model was used to: (1) study the relationship between wavelength and AF perpetuation in the presence of multiple re-entrant wavelets, (2) evaluate the performance of different existing methods for wavelength estimation in the presence of different arrhythmogenic substrates, and (3) document the impact of either heterogeneities in refractoriness or the presence of a mother rotor on wavelength estimation. Results The simulations confirmed that the wavelength must be below a critical value for AF to be sustained, when the perpetuation mechanism relies on multiple re-entrant wavelets. The estimated value of wavelength was not the same for all methods tested and depended in part on the nature of the spatio-temporal organization of the AF dynamics. Conclusion A priori information about the underlying wavelet dynamics is needed for a correct interpretation of the cardiac wavelength as estimated by the current clinical methods.
Jacquemet et al. (2005) studied Atrial fibrillation. Computer model of human atria was evaluated on Relationship between wavelength and AF perpetuation. A biophysically based computer model confirmed that cardiac wavelength must be below a critical value for atrial fibrillation to be sustained via multiple re-entrant wavelets.
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