What question did this study set out to answer?

This research investigates the role of MEF2A in peritoneal fibrosis and examines its regulatory mechanisms.

May 20, 2026Open Access

MEF2A nuclear translocation mediated by ROCK phosphorylation promotes EZH2 expression and peritoneal fibrosis

Key Points

This research investigates the role of MEF2A in peritoneal fibrosis and examines its regulatory mechanisms.
Utilized MEF2A knockdown in rats to assess fibrosis effects during long-term peritoneal dialysis (PD).
Administered oral fasudil treatment to inhibit MEF2A and EMT markers in dialysis-induced conditions.
MEF2A knockdown significantly reduced peritoneal fibrosis in rats (p<0.05).
Oral fasudil effectively inhibited MEF2A upregulation and EMT markers during dialysis, indicating a potential therapeutic approach.

Abstract

, MEF2A knockdown alleviated PF in rats undergoing to long-term PD. Consistently, oral fasudil treatment inhibited the dialysis-induced upregulation of MEF2A and EMT markers. These results reveal a novel ROCK/MEF2A/EZH2 axis in PF pathogenesis, highlighting MEF2A as a potential therapeutic target.

MEF2A nuclear translocation mediated by ROCK phosphorylation promotes EZH2 expression and peritoneal fibrosis

Key Points

Abstract

Cite This Study